| 体内研究: |
Piromelatine (20 mg/kg, ip, daily) treatment prevents insulin resistance induced by sleep restriction. Piromelatine (5-50 mg/kg, ip, daily) decreases plasma glucose significantly. Piromelatine (100 mg/kg) decreases thermal hyperalgesia and mechanical allodynia in PSL (partial sciatic nerve ligation) mice. |
| 参考文献: |
1. Meihua She, et al. Piromelatine, a Novel Melatonin Receptor Agonist, Stabilizes Metabolic Profiles and Ameliorates Insulin Resistance in Chronic Sleep Restricted Rats. Eur J Pharmacol. 2014 Mar 15;727:60-5. 2. L Huang, et al. Blood Pressure Reducing Effects of Piromelatine and Melatonin in Spontaneously Hypertensive Rats. Eur Rev Med Pharmacol Sci. 2013 Sep;17(18):2449-56. 3. Yuan-Yuan Liu, et al. Piromelatine Exerts Antinociceptive Effect via Melatonin, Opioid, and 5HT1A Receptors and Hypnotic Effect via Melatonin Receptors in a Mouse Model of Neuropathic Pain. Psychopharmacology (Berl). 2014 Oct;231(20):3973-85. |
| 保存条件: |
避光,-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
3.202 ml |
16.009 ml |
32.018 ml |
| 5 mM |
0.64 ml |
3.202 ml |
6.404 ml |
| 10 mM |
0.32 ml |
1.601 ml |
3.202 ml |
| 50 mM |
0.064 ml |
0.32 ml |
0.64 ml |
|
| 注意: |
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