| 产品描述： | IRE1 抑制剂;IRE1 Inhibitors;;InformationMKC8866 MKC8866 (IRE1-IN-8866), a salicylaldehyde analog, is a specific IRE1α RNase inhibitor with IC50 of 0.29 μM for human IRE1α in vitro.TargetshIRE1α (Cell-free assay) 0.29 μMIn vitroMKC8866 is optimized and refined from a family of IRE1α-specific endoribonuclease inhibitors obtained from a chemical library screen. MKC8866 effectively represses IRE1α-mediated XBP1 splicing in PCa cells and has favorable pharmacokinetic and pharmacodynamic properties.In vivoMKC8866 is an IRE1α RNase-specific inhibitor molecule that displays significant therapeutic activity in various preclinical models of PCa in vivo. MKC8866 synergizes with clinical PCa drugs in vivo.Cell Research(from reference)Cell lines：human PCa cell lines LNCaP and 22Rv1, VCaP cell line, C4-2B cell line Concentrations：0.2-10 μM Incubation Time：0.25-24 h |
| 靶点： |
IC50: 0.29 μM (IRE1 RNase) |
| 体内研究： |
MKC8866 (口服；300 mg/kg；持续 28 天)可减少 NSC 125973 停药后的肿瘤再生。 |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.767 ml |
13.837 ml |
27.674 ml |
| 5 mM |
0.553 ml |
2.767 ml |
5.535 ml |
| 10 mM |
0.277 ml |
1.384 ml |
2.767 ml |
| 50 mM |
0.055 ml |
0.277 ml |
0.553 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京