货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T88554-1ml促销	2mM in DMSO	￥1700.00 ￥1350.00 T88554-1ml ￥1350.00 现货	4 4	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T88554-1ml促销

2mM in DMSO

￥1700.00 ￥1350.00

产品描述：

GluR 调节剂;GluR Modulators;;InformationJNJ-42153605 JNJ-42153605 is a potent and selective mGlu2 receptor positive allosteric modulator with an EC50 of 17 nM.TargetsmGlu2 receptor 17 nM(EC50)In vitroJNJ-42153605 is found to not have agonist or antagonist activity toward other mGlu receptor subtypes up to 30 μM (>50-fold vs mGluR2) and also shows no or negligible affinity or activity at any of the targets in the CEREP panel of receptors (>100-fold selectivity for mGlu2 receptor).In vivoIn mice, JNJ-42153605 dose-dependently and significantly attenuates the increase in locomotor activity induced by phencyclidine (PCP, 5 mg/kg sc) with an ED50 of 5.4 mg/kg sc. JNJ-42153605 shows a rapid rate of absorption from the gastrointestinal tract, reaching the maximal concentration after 0.5 h. Clearance in vivo is moderate to high in both rat and dog (35 and 29 mL/min/kg, respectively). Elimination halflives are on the shorter side across the species, being 2.7 h in rat and 0.8−1.1 h in dog. Volume of distribution is slightly higher than total body water, indicating distribution outside the plasma. Bioavailability is low to moderate across the species (35% in rat and 18−33% in dog).

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.497 ml	12.486 ml	24.973 ml
5 mM	0.499 ml	2.497 ml	4.995 ml
10 mM	0.25 ml	1.249 ml	2.497 ml
50 mM	0.05 ml	0.25 ml	0.499 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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