| 体内研究: |
A gas chromatographic method has been developed which enables accurate determination of a new antihypertensive agent, DU-717, in plasma. Accurate determinations are possible over a concentration range from 10 to 150 ng/mL of DU-717 in plasma at a relative standard deviation of 6.2%. The minimum detectable concentration is 1 ng/mL. Plasma levels of DU-717 in spontaneously hypertensive and normotensive rats following single oral administrations (10 mg/kg) have also been determined. |
| 参考文献: |
1. Yamaguchi T, et al. Determination of 7-chloro-3-(4-methyl-1-piperazinyl)-4h-1,2,4-benzothiadiazine-1,1-dioxide (DU-717) in plasma using electron-capture gas chromatography. J Chromatogr. 1978 Oct 11;160(1):181-90. 2. R Horie. rats (ALR) and normotensive atherogenic rats (NAR). |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
3.177 ml |
15.883 ml |
31.767 ml |
| 5 mM |
0.635 ml |
3.177 ml |
6.353 ml |
| 10 mM |
0.318 ml |
1.588 ml |
3.177 ml |
| 50 mM |
0.064 ml |
0.318 ml |
0.635 ml |
|
| 注意: |
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