| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T90183-1ml |
10mM in DMSO | ￥206.00 |
5 | - | - | - | - |
|
| 产品描述： | Product Describtion:Amsacrine hydrochloride is a DNA topoisomerase II inhibitor.Product Application：Amsacrine: A DNA Intercalator with the Inhibition of Topoisomerase IIAmsacrine (known as m-AMSA) hydrochloride is an acridine derivative that has a potent antitumor activity against leukemic cells. Amsacrine inhibits topoisomerase II which is a group of essential enzymes for DNA replication with important functions for DNA function and cell survival. Topoisomerase II is now viewed as an important cellular target of antitumor drugs including both DNA intercalators (amsacrine and doxorubicin [D4193]) and the nonintercalator epipodophyllotoxin derivatives (etoposide [E0675] and teniposide [T3109]). Amsacrine is often used in combination with other chemotherapy drugs to treat types of adult leukemia, particularly acute myeloid leukemia (AML). (The product is for research purpose only.) | ||||||||||||||||||||
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| 体内研究： | 在用不同剂量的 Amsacrine hydrochloride (0.5-12 mg/kg) 处理的动物中，微核多染红细胞的频率在 9 和 12 mg/kg 处理剂量下显著增加。此外，本研究首次证明 Amsacrine hydrochloride (mAMSA) 在体内有丝分裂期具有高致染色体断裂发生率和低致染色体断裂发生率，而 Nocodazole 在体内有丝分裂期具有高致染色体断裂发生率和低致染色体断裂发生率。 | ||||||||||||||||||||
| 保存条件： | -80℃（运输条件：冰袋低温运输） | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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