| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T90244-1ml促销 |
10mM in DMSO | ￥206.00 ￥185.00 |
4 | - | - | - | - |
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| 产品描述： | Nrf2通路的激活剂；DMF的主要代谢物;Activator of Nrf2 pathway; primary metabolite ofDMF(Cat. No. 4512);mono-Methyl fumarate can be used as a reactant to synthesize: · Jumonji C domain-containing histone demethylases (JCHDMs) inhibitor. · (-)-Xylariamide A, a fungal metabolite. · (±)-Methoxyfumimycin ethyl ester, a potential bacterial peptide deformylase inhibitor. It is also a wide spectrum antibacterial agent with a powerful antioxidant activity.;mono-Methyl fumarate can be used as a reactant to synthesize: · Jumonji C domain-containing histone demethylases (JCHDMs) inhibitor. · (-)-Xylariamide A, a fungal metabolite. · (±)-Methoxyfumimycin ethyl ester, a potential bacterial peptide deformylase inhibitor. It is also a wide spectrum antibacterial agent with a powerful antioxidant activity. | ||||||||||||||||||||
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| 体内研究： | 曝光前单剂量Monomethyl fumarate (50-100 mg/kg；i.p) 以剂量依赖性方式防止这些形态变化 (强光曝光诱导的光感受器死亡)。 Monomethyl fumarate (100 mg/kg) 减少视网膜炎症和氧化应激。Monomethyl fumarate显著抑制 NFkB 通路中光诱导的视网膜病变 (LIR) 上调基因，包括：Nlrp3、Casp1、Il-1β 和 Tnf-α。 |
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| 参考文献： | 1. Tang H, et al. The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. Biochem Biophys Res Commun. 2008 Oct 31;375(4):562-5. 2. Jiang D, et al. Monomethyl Fumarate Protects the Retina From Light-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):1275-1285. 3. Sghaier R, et al. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrialalterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. J Steroid Biochem Mol Biol. 2019 Nov;194:105432. |
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| 保存条件： | -80℃（运输条件：冰袋低温运输） | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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