| 产品描述: | 在潮湿空气中易吸潮,高温分解,易溶于水及醇;微溶于醚. ;Citric Acid is an acidic compound from citrus fruits; as a starting point in the Krebs cycle, citrate is a key intermediate in metabolism. Citric acid is one of a series of compounds responsible for the physiological oxidation of fats, carbohydrates and proteins to carbon dioxide and water. Often used to prepare citrate buffer for antigen retrieval of tissue samples. The citrate solution is designed to break protein cross-links; thus, unmasking antigens and epitopes in formalin-fixed and paraffin embedded tissue sections, resulting in enhancing staining intensity of antibodies. Citrate has anticoagulant activity; as a calcium chelator, it forms complexes that disrupt the tendency of blood to clot. May be used to adjust pH and as a sequestering agent for the removal of trace metals.Used in the preparation of citrate buffer for antigen and epitope unmasking in IHC. |
| 体内研究: |
Citric acid (120, 240, 和 480 mg/kg; 腹腔注射) 显著降低小鼠肝脏 GSH-Px 活性,诱导 MDA (丙二醛) 水平升高。 Citric acid (120、240 和 480 mg/kg;腹腔注射) 在小鼠肝细胞中通过增加 caspase-3 活性以剂量依赖性方式诱导细胞凋亡。 Citric acid (120、240 和 480 mg/kg;腹腔注射;每周注射,连续 3 周) 引起小鼠肾毒性。 |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
5.205 ml |
26.025 ml |
52.051 ml |
| 5 mM |
1.041 ml |
5.205 ml |
10.41 ml |
| 10 mM |
0.521 ml |
2.603 ml |
5.205 ml |
| 50 mM |
0.104 ml |
0.521 ml |
1.041 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |