| 产品描述： | 特定的烟草生物碱;a specific tobacco alkaloid;麦斯明是一种次要的烟草生物碱，已显示通过吡啶基氧代丁基化作用对DNA造成损伤，对细胞具有遗传毒性作用。研究表明，在细胞中，肌苷可以被H | 2 | O | 2 |和3-吗啉代亚砜亚胺活化为反应性中间体。已知肌氨酸在酸性pH下经历环链互变异构，并以氨基酮形式存在。此外，Myosmine是用于监测烟草烟雾对细胞影响的理想工具。;Product DescriptionMyosmine is a minor tobacco alkaloid which has been shown to possess genotoxic effects on cells through DNA damage by pyridyloxobutylation. Studies indicate that in cells Myosmine can be activated into reactive intermediates by H|2|O|2| and 3-morpholinosydnonimine . It is known that under acidic pH Myosmine undergoes a ring-chain tautomerism and is present in the amino-keto form. Furthermore, Myosmine is an ideal tool to use to monitor the effects of tobacco smoke on cells.Product ApplicationNitrosation reactions；Peroxidation reaction with hydrogen peroxide |
| 靶点： |
Ki: 3300 nM (a4b2 nAChR) and >10 µM (AT1) |
| 体内研究： |
Myosmine (0.001, 0.005, 0.5, and 50 micromol/kg; oral; in Wistar rats) causes a higher percentage of the radioactivity excreted in urine (86.2% and 88.9%) at the two lower doses (0.001 and 0.005 micromol/kg),as compared with the higher doses (0.5 and 50 micromol/kg), where only 77.8% and 75.4% of the dose is found in urine. |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
6.84 ml |
34.202 ml |
68.404 ml |
| 5 mM |
1.368 ml |
6.84 ml |
13.681 ml |
| 10 mM |
0.684 ml |
3.42 ml |
6.84 ml |
| 50 mM |
0.137 ml |
0.684 ml |
1.368 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京