RXR激动剂;RXR agonist;DHA是一种必需脂肪酸,其在神经组织中属最丰富的ω-3脂肪酸,特别是在视网膜和大脑。DHA构成高达40%的视网膜和神经细胞膜的多不饱和脂肪酸总量池。使用鱼油DHA膳食补充剂,可抑制动脉粥样硬化和延误光感受器变性的视网膜色素变性的进度。新生儿的DHA不足会导致发育缺陷,大鼠DHA不足可能导致高血压。;DHA is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. DHA constitutes as much as 40% of the total PUFA pool in retinal and neuronal membranes. Supplementation of dietary DHA using fish oil inhibits the progression of atherosclerosis and delays photoreceptor degeneration in retinitis pigmentosa. Neonatal DHA deprivation causes developmental defects and can lead to hypertension in rats.Docosahexaenoic acid, DHA, is an omega-3 polyunsaturated fatty acid with 22 carbons and six double bonds, the first double bond occuring at position three from the methyl terminus (22:6 n-3). DHA is a component of lipid membranes and the myelin sheath. DHA also serves as a precursor for signaling molecules such as prostaglandins and eicosanoids.