| 产品描述： | (+)-Borneol, a bicyclic monoterpene, is found in the essential oils of medicinal plants and is commonly used in traditional Chinese medicine for analgesia and anaesthesia.;(+)-Borneol, a bicyclic monoterpene, is found in the essential oils of medicinal plants and is commonly used in traditional Chinese medicine for analgesia and anaesthesia.(+)-Borneol has been used to study its antiapoptotic, antioxidative and neuroprotective effect in human neuroblastoma cells (SH-SY5Y). |
| 靶点： |
EC50: 248 μM (GABA receptor) |
| 体内研究： |
(+)-Borneol has remarkable anti-hyperalgesic effects on neuropathic and inflammatory pain in animal models. Both oral administration (125, 250 or 500 mg/kg) and intrathecal injection (i.t.) (15, 30 and 60 μg) of (+)-Borneol reduce mechanical hypersensitivity dose-dependently in SNL and CFA models. The antihyperalgesic effects of (+)-Borneol are abolished by a selective GABAA receptor (GABAAR) antagonist bicuculline. (+)-Borneol (500 mg/kg, p.o. or 60 μg, i.t.) does not influence motor function. After per oral application, (+)-Borneol is absorbed rapidly into the brain and could be determined 5 min after dosing. The maximal brain concentration (86.52 μg/g) is reached after 1 h post-dosing. (+)-Borneol could affect the contents of AA neurotransmitters in mice brain and the change in excitatory ratio leads to borneol's double side effects on the central nervous system. |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
6.483 ml |
32.415 ml |
64.83 ml |
| 5 mM |
1.297 ml |
6.483 ml |
12.966 ml |
| 10 mM |
0.648 ml |
3.241 ml |
6.483 ml |
| 50 mM |
0.13 ml |
0.648 ml |
1.297 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京