| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T90679-1ml促销 |
10mM in DMSO | ￥426.00 ￥340.00 |
6 | - | - | - | - |
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| 产品描述： | Ca 2+释放调节剂;Ca 2+ release modulator;2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3.;2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3. | ||||||||||||||||||||
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| 靶点： | Inositol triphosphate receptor (IP3R) | ||||||||||||||||||||
| 体内研究： | 2-Aminoethyl diphenylborinate (0.5 或 2 mg/kg，腹腔注射，给药时长 24 小时) 在蛛网膜下腔出血 (SAH) 大鼠模型中 (通过右侧股动脉血注射入大脑小脑池诱导)，表现出对血管痉挛的抑制作用。 2-Aminoethyl diphenylborinate (2 或 4 mg/kg，腹腔注射，单次给药 10 分钟) 在缺血后再灌注诱导的睾丸损伤大鼠模型中减少了细胞的氧化应激和凋亡。 2-Aminoethyl diphenylborinate (2 mg/kg，经门静脉注射，缺血处理前 10 分钟注射) 在缺血后再灌注引起肝脏损伤的大鼠模型中，可以有效预防肝脏 I/R 损伤。 |
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| 参考文献： | 1. Ma S, et al. Effect of Wilforine on the Calcium Signaling Pathway in Mythimna separata Walker MyocytesUsing the Calcium Imaging Technique. J Agric Food Chem. 2019 Nov 27. 2. Boyacı MG, et al. Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and OraiChannels in Subarachnoid Hemorrhage: An Experimental Study. 3. Takahashi K, et al. Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12. Exp Cell Res. 2014 May 1;323(2):337-45. 4. Sari E, et al. Protective effect of 2-APB on testicular ischemia-reperfusion injury in rats. J Urol. 2015 Mar;193(3):1036-41. 5. Nicoud IB, Knox CD, Jones CM, Anderson CD, Pierce JM, Belous AE, Earl TM, Chari RS. 2-APB protects against liver ischemia-reperfusion injury by reducing cellular and mitochondrial calcium uptake. Am J Physiol Gastrointest Liver Physiol. 2007 Sep;293(3):G623-30. |
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| 保存条件： | -80℃（运输条件：冰袋低温运输） | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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