“谷氨酸类似物”,作为谷氨酸脱羧酶抑制剂。;glutamate analogs as an inhibitor of glutamate decarboxylase.
靶点:
Ki: 33 μM (Glutamate decarboxylase).
参考文献:
1. Searcey M, et al. Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives. Anticancer Drug Des. 13(8):837-55. 2. Espinet P, et al. Mesogenic palladium complexes with pincer ligands derived from dipicolinic acid. Inorg Chem. 2000 Aug, 7;39(16):3645-51. 3. Porter TG, et al. Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase. Biochem Pharmacol. 1985 Dec 1;34(23):4145-50.