| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T91036-1ml促销 |
10mM in DMSO | ￥206.00 ￥185.00 |
7 | - | - | - | - |
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| 产品描述： | Diethylmaleate is a glutathione-depleting compound that has been shown to induce apoptosis. Reports indicate that Diethylmaleate inhibits NF κ B activation, activates PDAP1 (Pap1), and modifies the endoribonuclease action of 26S proteasomes. Diethylmaleate is an activator of GHS-R1α.;Diethylmaleate is a glutathione-depleting compound that has been shown to induce apoptosis. Reports indicate that Diethylmaleate inhibits NF κ B activation, activates PDAP1 (Pap1), and modifies the endoribonuclease action of 26S proteasomes. Diethylmaleate is an activator of GHS-R1α.A glutathione-depleting compound that inhibits NF kappa B. | ||||||||||||||||||||
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| 体内研究： | Diethyl maleate (4.6 mmol/kg；腹腔注射；单次；2 h) 使 Sprague-Dawley 大鼠肺/脑组织谷胱甘肽 (GSH) 减少 82%/45%，并缩短高压氧暴露下的惊厥/死亡时间。 Diethyl maleate (4.6 mmol/kg；腹腔注射；单次；24 h）在组织 GSH 水平恢复后不增强高氧毒性。Diethyl maleate (4.6 mmol/kg；腹腔注射；单次 + 90 分钟后补充等摩尔 GSH）逆转 GSH 耗竭并恢复高氧暴露大鼠存活时间。 |
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| 参考文献： | 1. Andrea Gille, et al. Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate. Redox Biol. 2019 Jan;20:19-27. 2. Weber CA, et al. Depletion of tissue glutathione with diethyl maleate enhances hyperbaric oxygen toxicity. Am J Physiol. 1990 Jun;258(6 Pt 1):L308-12. 3. Deneke SM, et al. Increase in endothelial cell glutathione and precursor amino acid uptake by diethyl maleate and hyperoxia. Am J Physiol. 1989 Oct;257(4 Pt 1):L265-71. |
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| 保存条件： | -80℃（运输条件：冰袋低温运输） | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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