货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T91641-1ml	10mM in DMSO	￥84.00 T91641-1ml ￥84.00 现货	12 >10	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T91641-1ml

10mM in DMSO

￥84.00

>10

产品描述：

Product Application：4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.

参考文献：

1. Mohamed MA, et al. Synthesis and antitumor evaluation of trimethoxyanilides based on 4(3H)-quinazolinone scaffolds. Eur J Med Chem. 2016 Apr 13;112:106-113.
2. Qian Y, et al. Exploration of the Structural Space in 4(3H)-Quinazolinone Antibacterials[J]. J Med Chem. 2020 May 28;63(10):5287-5296.
3. Gatadi S, et al. 4(3H)-Quinazolinone derivatives: Promising antibacterial drug leads. Eur J Med Chem. 2019 May 15;170:157-172.

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	6.842 ml	34.211 ml	68.423 ml
5 mM	1.368 ml	6.842 ml	13.685 ml
10 mM	0.684 ml	3.421 ml	6.842 ml
50 mM	0.137 ml	0.684 ml	1.368 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

4-羟基喹唑啉

4-Hydroxyquinazoline

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)