| 产品描述： | 水中溶解度:5 g/l 。溶于乙醚和二甲基甲酰胺。175～177℃分解(先预热至170℃)，也有报道290℃也不熔化。最大吸收波长(pH5.2)265nm(ε 9120),(pH13)274nm(ε 8790)。;6-Chloropurine (6-CIPH), a 6-substituted purine derivative, is an antileukemic drug. It can be prepared by the chlorination of hypoxanthine with phosphorus oxychloride in the presence of dimethylaniline.The NMR-based conformational analysis of the products formed during the reaction of 6-CIPH with 3,4-di-O-acetyl-D-xylal and 3,4-di-O-acetyl-L-arabinal have been reported.6-CIPH can undergo palladium-catalyzed cross coupling with organostannanes at 6-position to form the corresponding arylated or alkylated products. |
| 体内研究： |
6-Chloropurine to S-(6-punnyl)glutathione and further metabolism of S-(6-punnyl)glutathione to 6-mercaptopunne may be involved in the mechanism of the 6-Chloropurine-induced antitumor activity. 6-chloropurine and azaserine have been shown to have synergic antitumor properties in a variety of mouse neoplasms when administered simultaneously. |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
6.47 ml |
32.35 ml |
64.7 ml |
| 5 mM |
1.294 ml |
6.47 ml |
12.94 ml |
| 10 mM |
0.647 ml |
3.235 ml |
6.47 ml |
| 50 mM |
0.129 ml |
0.647 ml |
1.294 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京