货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T92660-1ml促销	10mM in DMSO	￥809.00 ￥728.00 T92660-1ml ￥728.00 现货	5 5	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T92660-1ml促销

10mM in DMSO

￥809.00 ￥728.00

产品描述：

SIRT1 / 2抑制剂;SIRT1/2 inhibitor;产品介绍：Cambinol 是一种 SIRT1 和 SIRT2 的抑制剂，IC50 值分别为 56 μM 和 59 μM。Cambinol 是中性鞘磷脂酶 (N-SMase) 的抑制剂(外泌体抑制剂)。;application：Cambinol has been used:as an inhibitor of sirutins (SIRT1 and 2) in hepatocarcinoma cell lines to test its effect on cellular viability and colony formationas a SIRT1 and SIRT2 inhibitor to test its effect on frizzled 7 (FZD7) expression in the breast cancer cells MDA-MB-231 and T-47D cellsas a sirutin inhibitor in L929 cells to test its protective effect against tumor necrosis factor (TNF)-induced cell death.Biochemical mechanism:Cambinol is a Sirtuin (Human Silent Information Regulator) Type 1/2 Inhibitor. Sirtuins are structurally and mechanistically unrelated to HDACs Class 1 & 2 deacetylases but share many protein targets. HDAC is a large complex enzyme family involved in epigenetic-control of gene expression. Sirt2 has an IC50 equal to 59 μM.Cambinol, a β-naphthol compound, elicits antitumor activity and impairs the mitogen-activated protein kinase (MAPK) signaling. It has ability to inhibit the secretion of inflammatory cytokines including the tumor necrosis factor and interleukins. Cambinol can be a potential therapeutic agent for treating inflammatory diseases. It also aids protection in events of endotoxic and septic shock.

保存条件：

避光,-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.774 ml	13.872 ml	27.745 ml
5 mM	0.555 ml	2.774 ml	5.549 ml
10 mM	0.277 ml	1.387 ml	2.774 ml
50 mM	0.055 ml	0.277 ml	0.555 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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