货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T92896-1ml	10mM in DMSO	￥312.00 T92896-1ml ￥312.00 现货	7 7	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T92896-1ml

10mM in DMSO

￥312.00

产品描述：

H1 受体选择性抑制剂| 激动剂 | 拮抗剂;H1 receptor Selective Inhibitors | Agonists | Antagonists;;InformationEmedastine is a potent, high affinityhistamine H1-receptor-selectiveantagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (K1 = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM).TargetsH1 receptor (Cell-free assay) 1.3 nM(Ki)In vitroEmedastine is capable of potently inhibiting histamine-induced cytokine release as well as the chemotaxis of eosinophils, thereby influencing factors contributing to the inhibition of the signs and symptoms of allergic diseases.In vivoIn human, the half-life of emedastine, when administered as slow release capsules is of about 6±7 h.

体内研究：

Emedastine (0.03, 0.1, 0.3 mg/kg; orally; pretreatment of 30 min) significantly suppresses histamine-induced scratching with 0.1 and 0.3 mg/kg but not 0.03 mg/kg.
Pretreatment with Emedastine (0.03, 0.1, 0.3 mg/kg; orally) significantly inhibits the scratching induced by substance P and leukotriene B.
Emedastine (0.3 mg/kg, p.o.) produces significant inhibition of passive peritoneal anaphylaxis in guinea-pigs.
Emedastine inhibits histamine-induced contractions of isolated ileum (IC50=6.1 nM).

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.307 ml	16.534 ml	33.068 ml
5 mM	0.661 ml	3.307 ml	6.614 ml
10 mM	0.331 ml	1.653 ml	3.307 ml
50 mM	0.066 ml	0.331 ml	0.661 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

依美斯汀

Emedastine

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)