mTOR抑制剂;mTOR Inhibitors;;InformationGNE-493 GNE-493 (compound 5) is a potent, selective and orally available dual inhibitor of pan- PI3-kinase and mTOR with IC50 of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively.