货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T93111-1ml促销	10mM in DMSO	￥720.00 ￥648.00 T93111-1ml ￥648.00 现货	10 10	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T93111-1ml促销

10mM in DMSO

￥720.00 ￥648.00

产品描述：

STAT3 选择性抑制剂 | 活化剂;STAT3 Selective Inhibitors | Activators;;InformationHO-3867, an analog of curcumin, is a selectiveSTAT3inhibitor that inhibits its phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. HO-3867 inducesapoptosis.TargetsSTAT3In vitroHO-3867 produces significant cytotoxicity in A2780 and other tested ovarian cancer cell lines, with less toxic to noncancerous ovarian surface epithelial cells. HO-3867 induces G(2)-M cell cycle arrest in A2780 cells and promotes apoptosis by caspase-8 and caspase-3 activation. HO-3867 blocks the JAK/STAT3 pathway in human ovarian cancer cell lines.In vivoHO-3867 (100 ppm p.o.) inhibits the growth of ovarian cancer xenograft tumor in mice without any apparent signs of toxicity, and also results in inhibition of pSTAT3 as well as downregulation of the STAT3-targeting proteins. HO-3867 sensitizes cisplatin-resistant ovarian carcinoma through STAT3 inhibition. HO-3867 (100 ppm p.o.) also attenuates left-heart-failure-induced pulmonary hypertension by decreasing oxidative stress and increasing PTEN expression in the lung of rats.Cell Research(from reference)Cell lines：A2780 (A2780R), PA-1, SKOV3, OV4, and OVCAR3 cells; human ovarian surface epithelial cell Concentrations：~20 μM Incubation Time：24 hours

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.153 ml	10.763 ml	21.526 ml
5 mM	0.431 ml	2.153 ml	4.305 ml
10 mM	0.215 ml	1.076 ml	2.153 ml
50 mM	0.043 ml	0.215 ml	0.431 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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