InformationP7C3-A20 is a highly active analogue of P7C3. P7C3-A20 is neuroprotective and promotes endogenous reparative strategies after TBI (Traumatic brain injury).
体内研究:
P7C3-A20 (5-10?mg/kg; intraperitoneal injection; daily; for 7 days; Sprague-Dawley rats) 可减少梗塞体积;在 HI 模型大鼠中逆转皮质和海马体中的细胞损失并改善运动功能而不引起神经毒性。P7C3-A20 通过激活 PI3K/AKT/GSK3β 信号通路防止 HI 诱导的神经元损伤。