货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T93197-1ml促销	10mM in DMSO	￥720.00 ￥648.00 T93197-1ml ￥648.00 现货	9 9	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T93197-1ml促销

10mM in DMSO

￥720.00 ￥648.00

产品描述：

HSP(HSP90)抑制剂;HSP(HSP90) Inhibitors;;InformationNMS-E973 NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.TargetsHSP90 <10 nM(DC50)In vitroNMS-E973 shows a widespread antiproliferative activity with an average IC50 of 1.6 μM, and induces the degradation of client protein, such as Flt3, B-Raf, AKT, which further blocks tumor-related pathways, such as the Raf/MAPK, PI3K/AKT, and JAK/STAT pathways.In vivoNMS-E973 (10 mg/kg i.v.) shows a favorable pharmacokinetic profile with selective retention in tumor tissue and ability to cross the BBB. NMS-E973 (60 mg/kg i.v.) shows high antitumor efficacy in all the models tested, including A375 and A2780 xenografts. In addition, NMS-E973 (10 mg/kg i.v.) together with B-Raf inhibitor PLX-4720 at 100 mg/kg produces a synergic anti-tumor effect. In a mouse model of human ovarian cancer, NMS-E973 produces the antitumor activity by inhibition of Hsp90.Cell Research(from reference)Cell lines：140 human tumor cell lines of various tissue origins and molecular background. Concentrations：~10 μM

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.201 ml	11.003 ml	22.006 ml
5 mM	0.44 ml	2.201 ml	4.401 ml
10 mM	0.22 ml	1.1 ml	2.201 ml
50 mM	0.044 ml	0.22 ml	0.44 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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