TMP195 处理通过调节巨噬细胞表型改变肿瘤微环境并减少肿瘤负荷和肺转移。TMP195 诱导肿瘤内高度吞噬和刺激性巨噬细胞的募集和分化。在此模型中,将 TMP195 与化疗方案或 T 细胞检查点阻断相结合可显著增强肿瘤缩小的持久性。
参考文献:
1. Lobera M, et al. Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25. 2. Guerriero JL, et al. Class IIa HDAC inhibition reduces breast tumors and metastases through anti-tumor macrophages. Nature. 2017 Mar 16;543(7645):428-432.