强大的小分子IDO途径抑制剂;Potent, small molecule IDO pathway inhibitor;NLG919是一种有效的IDO (indoleamine-(2,3)-dioxygenase)通路抑制剂,无细胞试验中Ki/EC50为 7 nM/75 nM。;NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM in cell-free assays.
参考文献:
1. Coletti A, et al. Fragment-based approach to identify IDO1 inhibitor building blocks. Eur J Med Chem. 2017 Dec 1;141:169-177.