货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T93355-1ml促销	10mM in DMSO	￥720.00 ￥648.00 T93355-1ml ￥648.00 现货	10 10	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T93355-1ml促销

10mM in DMSO

￥720.00 ￥648.00

产品描述：

IKK 选择性抑制剂 | 调节剂;IKK Selective Inhibitors | Modulators;;InformationWS6 is a β cell proliferation inducer via modulation ofErb3 binding protein-1 (EBP1)and theIκB kinasepathway.TargetsEBP1 ; IκB kinaseIn vitroWS6 induces R7T1 cell proliferation with EC50 of 0.28 μM, and promotes β cell proliferation in rodent and human primary islets. Both Erb3 binding protein-1 and the IκB kinase pathway are confirmed to function in the mechanism of action of WS6.In vivoIn RIP-DTA mouse model of β cell ablation, WS6 (50 mg/kg p.o.) ameliorates diabetes, and induces concomitant increases in β cell proliferation and β cell number.Cell Research(from reference)Cell lines：R7T1 cells Concentrations：~10 μM Incubation Time：4 days

靶点：

EBP1, IkB.

体内研究：

WS6 (2.2 mg/kg; 1 天 1 次; 28 天; 腹腔注射) 通过增强慢性不可预测轻度应激 (CUMS) 模型大鼠海马体中的 GABA 信号传导和树突密度来缓解大鼠的抑郁样行为。

参考文献：

1. Boerner BP, George NM, Mir SU, Sarvetnick NE. WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability. Endocr J. 2015;62(4):379-86.
2. Zhang H, et al. WS6 Induces Adult Hippocampal Neurogenesis in Correlation to its Antidepressant Effect on the Alleviation of Depressive-like Behaviors of Rats. Neuroscience. 2021 Oct 1;473:119-129.
3. Massudi H, et al. Inhibitors of the Oncogenic PA2G4-MYCN Protein-Protein Interface. Cancers (Basel). 2023 Mar 17;15(6):1822.
4. Bregante J, et al. Efficacy and Synergy of Small Molecule Inhibitors Targeting FLT3-ITD+ Acute Myeloid Leukemia. Cancers (Basel). 2021 Dec 8;13(24):6181.
5. Zhang J, et al. ERBB2 signaling drives supporting cell proliferation in vitro and apparent supernumerary hair cell formation in vivo in the neonatal mouse cochlea. Eur J Neurosci. 2018 Nov;48(10):3299-3316.
6. Firdoos S, et al. In silico identification of novel stilbenes analogs for potential multi-targeted drugs against Alzheimer's disease. J Mol Model. 2023 Jun 14;29(7):209.

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.759 ml	8.794 ml	17.587 ml
5 mM	0.352 ml	1.759 ml	3.517 ml
10 mM	0.176 ml	0.879 ml	1.759 ml
50 mM	0.035 ml	0.176 ml	0.352 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置