货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T93360-1ml促销	10mM in DMSO	￥720.00 ￥648.00 T93360-1ml ￥648.00 现货	10 10	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T93360-1ml促销

10mM in DMSO

￥720.00 ￥648.00

产品描述：

AMPK 活化剂;AMPK Activators;;InformationIM156 IM156 (HL156A), a metformin derivative, is a potent activator of AMPK that increases AMPK phosphorylation. IM156 blocks oxidative phosphorylation (OXPHOS) through the inhibition of complex I and increases apoptosis . IM156 ameliorates various types of fibrosis and inhibits tumors.TargetsAMPK ; OXPHOSIn vitroIM156 (HL156A) treatment of RPMCs inhibits HG-induced myofibroblast transdifferentiation and markers of epithelial-mesenchymal transition (EMT). Moreover, IM156 (HL156A) ameliorates HG-induced transforming growth factor-β1, Smad3, Snail, and fibronectin expression in the RPMCs via AMPK upregulation. IM156 treatment decreases complex I-dependent NADH oxidation in a significant, dose-dependent manner.In vivoIn vivo treatment of IM156 exacerbated the memory differentiation of virus-specific CD8+ T cells results in an increase in short-lived effector cells but decrease in memory precursor effector cells. Thus, IM156 treatment impaires the function of virus-specific memory CD8+ T cells, indicating that excessive AMPK activation weakens memory T cell differentiation, thereby suppressing recall immune responses.Cell Research(from reference)Cell lines：Rat peritoneal mesothelial cells (RPMCs) Concentrations：10 μM, 30 μM, 50 μM Incubation Time：24 h

靶点：

oxidative phosphorylation (OXPHOS)

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.172 ml	15.858 ml	31.717 ml
5 mM	0.634 ml	3.172 ml	6.343 ml
10 mM	0.317 ml	1.586 ml	3.172 ml
50 mM	0.063 ml	0.317 ml	0.634 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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