| 产品描述： | STAT3 选择性抑制剂 | 活化剂;STAT3 Selective Inhibitors | Activators;;InformationSH5-07 is a robust hydroxamic acid-basedSTAT3inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models.TargetsSTAT3In vitroSH5-07 blocks STAT3 DNA binding activity in vitro and in human glioma, breast, and prostate cancer cells and in v-Src-transformed murine fibroblasts. STAT3-dependent gene transcription is blocked along with Bcl-2, Bcl-xL, Mcl-1, Cyclin D1, c-Myc and Survivin expression.In vivoIn mouse xenograft models of glioma and breast cancer, administration of SH5-07 effectively inhibits tumor growth.Cell Research(from reference)Cell lines：Normal mouse fibroblasts (NIH3T3) Concentrations：0-8 μM Incubation Time：24-48 h |
| 体内研究： |
Tail vein injection or oral gavage delivery of SH5-07 or SH4-54 inhibits growth of 90-150 mm3 established subcutaneous mouse xenografts of human glioma (U251MG) and breast (MDA-MB-231) tumors that harbor aberrantly-active Stat3, associated with decreased c-Myc, Mcl-1 and Cyclin D1 expression. No significant changes in body weights, blood cell counts, or the gross anatomy of organs, or obvious signs of toxicity are observed. |
| 参考文献： |
1. Yue P,et al. Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo. Cancer Res. 2016 Feb 1;76(3):652-63. |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.598 ml |
7.992 ml |
15.984 ml |
| 5 mM |
0.32 ml |
1.598 ml |
3.197 ml |
| 10 mM |
0.16 ml |
0.799 ml |
1.598 ml |
| 50 mM |
0.032 ml |
0.16 ml |
0.32 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京