铁死亡抑制剂;Ferroptosis Inhibitors;;InformationSRS11-92 SRS11-92 (AA9), a Ferrostatin-1 (Fer-1) analogue, is a potent inhibitor of ferroptosis . SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM.TargetsHT-1080 ferroptotic cell death (Cell-based assay) 6 nM(EC50)In vitroSRS11-92 is efficacious in protecting human and mouse cellular models of FRDA treated with ferric ammonium citrate (FAC) and an inhibitor of glutathione synthesis (BSO). SRS11-92 decreases the cell death associated with frataxin knockdown in healthy human fibroblasts.Cell Research(from reference)Cell lines:murine I154F FRDA fibroblasts Concentrations:50 μM to 500 nM Incubation Time:48 h