货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T93410-1ml	10mM in DMSO	￥720.00 T93410-1ml ￥720.00 现货	9 9	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T93410-1ml

10mM in DMSO

￥720.00

产品描述：

Wnt/β-连环蛋白抑制剂;Wnt/beta-catenin Inhibitors;;InformationAdavivint (SM04690) Adavivint (SM04690) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ∼150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.TargetsWntIn vitroBone-marrow-derived hMSCs (CD29+, CD44+ CD166+ CD105+ CD45-), treated with SM04690, show a dose-dependent decrease in the expression of Wnt pathway genes (ASCL1, LEF1, TCF7L2, TCF7, C-262 MYC and AXIN2). M04690 also inhibits the expression of AXIN2, TCF7 and LEF1 in hMSCs and AXIN2 and LGR5 in IEC6 (intestinal stem cells sensitive to Wnt activation) when the Wnt pathway is selectively activated using either Wnt3a or a GSK3β inhibitor, CHIR-99021. SM04690 has minimal effects on the non-canonical Wnt pathway and the BMP pathway. SM04690 protects chondrocytes from catabolic breakdown in vitro.In vivoIntra-articular injection of SM04690 promotes cartilage growth and improves joint health in a rat model of knee osteoarthritis. It decreases cartilage breakdown in vivo.Cell Research(from reference)Cell lines：SW480 cells and hMSCs Concentrations：10, 30 and 100 nM Incubation Time：48 h

靶点：

EC50: 19.5 nM (Wnt, SW480 cell)

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.978 ml	9.89 ml	19.78 ml
5 mM	0.396 ml	1.978 ml	3.956 ml
10 mM	0.198 ml	0.989 ml	1.978 ml
50 mM	0.04 ml	0.198 ml	0.396 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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