| 产品描述： | Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting NADPH oxidase. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187. Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells. |
| 靶点： |
HMG-CoA Reductase |
| 体内研究： |
Pitavastatin Calcium (59 mg/kg；口服；每天两次，持续 28 天) 导致显著的肿瘤消退。 |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.135 ml |
5.675 ml |
11.351 ml |
| 5 mM |
0.227 ml |
1.135 ml |
2.27 ml |
| 10 mM |
0.114 ml |
0.568 ml |
1.135 ml |
| 50 mM |
0.023 ml |
0.114 ml |
0.227 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京