| 产品描述： | GHSR激动剂;GHSR Agonists;;InformationCapromorelin tartrate Capromorelin Tartrate (CP 424391-18), a member of the growth hormone secretagogue (GHS) class of drugs, is a ghrelin receptor agonist and a novel therapy for stimulation of appetite in dogs with Ki of 7 nM for hGHS-R1a and EC50 of 3 nM for rat pituicyte.Targetsrat pituicyte (Cell-free assay); hGHS-R1a (Cell-free assay) 3 nM(EC50); 7 nM(Ki) |
| 靶点： |
Ki: 7 nM (hGHS-R1a) |
| 体内研究： |
Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED50 of 0.05 mg/kg iv. |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.525 ml |
7.625 ml |
15.251 ml |
| 5 mM |
0.305 ml |
1.525 ml |
3.05 ml |
| 10 mM |
0.153 ml |
0.763 ml |
1.525 ml |
| 50 mM |
0.031 ml |
0.153 ml |
0.305 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京