货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T93691-1ml促销	10mM in DMSO	￥720.00 ￥648.00 T93691-1ml ￥648.00 现货	10 10	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T93691-1ml促销

10mM in DMSO

￥720.00 ￥648.00

产品描述：

NAMPT 活化剂;NAMPT Activators;;InformationSBI-797812 SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT . SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates NMN.TargetsNAMPTIn vitroSBI-797812 shifts the NAMPT reaction equilibrium towards NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT at His247, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD+. Treatment of cultured cells with SBI-797812 increases intracellular NMN and NAD+.In vivoPlasma concentrations of SBI-797812 after oral administration are low. Higher plasma levels of SBI-797812 are seen after i.p. dosing. The potency of SBI-797812 against mouse NAMPT is investigated. The apparent affinity (EC50) of SBI-797812 for mouse NAMPT is approximately 8-fold less than for human NAMPT, whereas maximal fold activation by SBI-797812 is comparable between the mouse and human NAMPT. Dosing of mice with SBI-797812 elevates liver NAD+.Cell Research(from reference)Cell lines：Human A549 lung carcinoma cells Concentrations：10 μM Incubation Time：4 h

靶点：

NAMPT

体内研究：

SBI-797812 (10 mg/kg；ip 或 op；单剂量) 通过腹膜内注射显示高血浆暴露，Cmax 值为 3297 ng/mL，8.2 μM。
SBI-797812 (20 mg/kg；腹腔注射；单剂量；给药后 2 小时测量) 显著增加小鼠肝脏中的 NAD+。

参考文献：

1. Gardell SJ , et al. Boosting NAD+ with a small molecule that activates NAMPT. Nat Commun. 2019 Jul 19;10(1):3241.
2. Khaidizar FD, et al. Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process. Int J Mol Sci. 2021 Apr 2;22(7):3709.

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.485 ml	12.423 ml	24.847 ml
5 mM	0.497 ml	2.485 ml	4.969 ml
10 mM	0.248 ml	1.242 ml	2.485 ml
50 mM	0.05 ml	0.248 ml	0.497 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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