货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T93720-1ml促销	10mM in DMSO	￥992.00 ￥892.00 T93720-1ml ￥892.00 现货	10 10	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T93720-1ml促销

10mM in DMSO

￥992.00 ￥892.00

产品描述：

TBK1 抑制剂;TBK1 Inhibitors;;InformationGSK8612 GSK8612 is a highly potent and selective inhibitor for TBK1 (Tank-binding Kinase-1) with pKd of 8.0. Within 10-fold affinity with respect to TBK1, no off-targets of GSK8612 could be identified.TargetsTBK1 6.8(pIC50)In vitroIn cellular assays, this small molecule inhibits toll-like receptor (TLR)3-induced interferon regulatory factor (IRF)3 phosphorylation in Ramos cells and type I interferon (IFN) secretion in primary human mononuclear cells. In THP1 cells, GSK8612 is able to inhibit secretion of interferon beta (IFNβ) in response to dsDNA and cGAMP, the natural ligand for STING. GSK8612 has lower affinity for phosphorylated TBK1. GSK8612 inhibits recombinant TBK1 with an average pIC50 of 6.8 in a biochemical functional assay. The actual selectivity of GSK8612 for TBK1 in the cells will depend on the activation state of TBK1.In vivoGSK8612 is highly protein bound in mouse, rat and human blood.

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.922 ml	9.609 ml	19.219 ml
5 mM	0.384 ml	1.922 ml	3.844 ml
10 mM	0.192 ml	0.961 ml	1.922 ml
50 mM	0.038 ml	0.192 ml	0.384 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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