| 产品描述: | NMDAR拮抗剂;NMDAR Antagonists;;InformationRadiprodil (RGH-896) Radiprodil (RGH-896) is a NR2B-selective NMDA receptor antagonist, initially developed for the treatment of neuropathic pain. |
| 靶点: |
NMDA NR2B. |
| 体内研究: |
Radiprodil could block NMDA currents in Mg2+ insensitive variants, with potencies similar to those obtained without Mg2+. Radiprodil's potency is higher at pH 7.0 than at pH 7.6, suggesting that radiprodil may retain its ability to block glutamate-induced NMDA currents even under acidic conditions that manifest under long term seizures. |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
2.516 ml |
12.582 ml |
25.164 ml |
| 5 mM |
0.503 ml |
2.516 ml |
5.033 ml |
| 10 mM |
0.252 ml |
1.258 ml |
2.516 ml |
| 50 mM |
0.05 ml |
0.252 ml |
0.503 ml |
|
| 注意: |
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