货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T94132-1ml促销	10mM in DMSO	￥852.00 ￥680.00 T94132-1ml ￥680.00 现货	10 10	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T94132-1ml促销

10mM in DMSO

￥852.00 ￥680.00

产品描述：

甘油单酯脂肪酶（MGL）的选择性抑制剂;Selective inhibitor of monoglycerol lipase (MGL);URB602 是一种选择性的单酰基甘油脂肪酶 (MGL) 抑制剂，非竞争性抑制大鼠脑 MGL，IC50 为 28±4 μM。;URB602 is a selective monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL with IC50 of 28±4 μM through a noncompetitive mechanism.

靶点：

IC50: 28±4 μM (rat brain MGL)

体内研究：

URB602 at doses of 20 and 40 mg/kg tends to reduce upper GI transit and slow colonic propulsion. When taken together as whole gut transit, URB602 dose dependently inhibits transit (P<0.05) compared with the vehicle control group. The inhibitory action of 40 mg/kg URB602 on whole gut transit is absent in these mice, indicating CB1 receptor involvement in the inhibitory action. URB602 decreases the AUC of pain behaviour during the early phase of the formalin test with an ED50 of 0.06±0.028 μg for JZL184 and 120±51.3 μg for URB602 in adult male Sprague-Dawley rats. Both MGL inhibitors also suppresses pain behaviour during the late phase of formalin pain, with an ED50 of 0.03±0.011 μg for JZL184 and 66±23.9 μg for URB602.

参考文献：

1. Hohmann AG, et al. An endocannabinoid mechanism for stress-induced analgesia. Nature. 2005 Jun 23;435(7045):1108-12.
2. King AR, et al. URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. Chem Biol. 2007 Dec;14(12):1357-65.
3. Duncan M, et al. Distribution and function of monoacylglycerol lipase in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1255-65.
4. Guindon J, et al. Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. Br J Pharmacol. 2011 Aug;163(7):1464-78.

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.385 ml	16.927 ml	33.855 ml
5 mM	0.677 ml	3.385 ml	6.771 ml
10 mM	0.339 ml	1.693 ml	3.385 ml
50 mM	0.068 ml	0.339 ml	0.677 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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