Tenoxicam是一种有效的自由基清除剂,IC50为56.7 μM。;Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM.A nonsteroidal, anti-inflammatory, analgesic agent.
体内研究:
Tenoxicam (Ro-12-0068) was administered intraperitoneally immediately after BCAO. Histological analyses show that ischemia produced significant striatal as well as hippocampal lesions which were reversed by the Tenoxicam (Ro-12-0068) treatment. Tenoxicam (Ro-12-0068) also significantly reduced, to control levels, the increased myeloperoxidase activity in hippocampus homogenates observed after ischemia.