钾通道抑制剂;Potassium Channel Inhibitors;应用:氧化前胡素是一种选择性的开放通道阻滞剂,可抑制 hKv1.5 通道电流,IC50 值为 76 nM。氧化前胡素延长心脏动作电位持续时间 (APD),是一种潜在的抗心律失常试剂。氧化前胡素通过抑制癌细胞迁移来诱导细胞凋亡 (apoptosis )。;InformationOxypeucedanin Oxypeucedanin is a major coumarin aglycone that can be extracted from Ostericum koreanum. It is a kind of open-channel blocker of the hKv1.5 channel .TargetshKv1.5 channel