货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T94956-1ml	10mM in DMSO	￥368.00 T94956-1ml ￥368.00 现货	6 6	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T94956-1ml

10mM in DMSO

￥368.00

产品描述：

脱氢酶抑制剂;Dehydrogenase Inhibitors;;InformationASLAN003 ASLAN003 (LAS 186323) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors.TargetsAP-1 ; human DHODH (Cell-free assay) ; 35 nMIn vitroASLAN003 is a highly potent dihydroorotate dehydrogenase inhibitor that induces differentiation, as well as reducing cell proliferation and viability, of AML cell lines and primary AML blasts including chemoresistant cells. Apoptotic pathways are triggered by ASLAN003, and this drug also significantly inhibits protein synthesis and activates AP-1 transcription, contributing to its capacity to promote differentiation.In vivoASLAN003 substantially reduces leukemic burden and prolongs survival in AML xenograft mice and AML patient-derived xenograft models. ASLAN003 has no evident effect on normal hematopoietic cells and exhibits excellent safety profiles in mice, even after a prolonged period of administration.Cell Research(from reference)Cell lines：MOLM-14 cells, KG-1 cells Concentrations：1 μM, 2 μM Incubation Time：1 h

靶点：

IC50: 35 nM (human DHODH enzyme)

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.806 ml	14.032 ml	28.065 ml
5 mM	0.561 ml	2.806 ml	5.613 ml
10 mM	0.281 ml	1.403 ml	2.806 ml
50 mM	0.056 ml	0.281 ml	0.561 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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