货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T95093-1ml促销	10mM in DMSO	￥720.00 ￥648.00 T95093-1ml ￥648.00 现货	3 3	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T95093-1ml促销

10mM in DMSO

￥720.00 ￥648.00

产品描述：

STAT3 选择性抑制剂 | 活化剂;STAT3 Selective Inhibitors | Activators;;Application：STA-21 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor to study its effects on glioblastoma and primary glioblastoma cells. It has also been used as a STAT3 dimerization inhibitor to study its effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) production in human lung cancer cell line.InformationOchromycinone (STA-21) is a selectiveSTAT3inhibitor.TargetsSTAT3In vitroIn cells, STA-21 inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity. STA-21 remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. In RH30 and RD2 cells, STA-21 also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways.In vivoIn IL-1Ra–KO mice, STA-21 (0.5 mg/kg, i.p.) reduces the arthritis score and the incidence of arthritis by decreasing the proportion of Th17 cells and increasing the proportion of Treg cells expressing FoxP3.Cell Research(from reference)Cell lines：MDA-MB-231, MDA-MB-435s, MDA-MB-453, MDA-MB-468, MCF7, and Caov-3 cells Concentrations：20 or 30 μM Incubation Time：48 h

靶点：

STAT3

参考文献：

1. Song H, et al. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4700-5.
2. Nataliya I. Kalinovskaya, et al. New Angucyclinones from the Marine Mollusk Associated Actinomycete Saccharothrix espanaensis An 113. Natural product communications. 2008, 3(10):1611-1616.

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.265 ml	16.323 ml	32.647 ml
5 mM	0.653 ml	3.265 ml	6.529 ml
10 mM	0.326 ml	1.632 ml	3.265 ml
50 mM	0.065 ml	0.326 ml	0.653 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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