| 产品描述： | JAK2 选择性抑制剂;JAK2 Selective Inhibitors;产品介绍：FLLL32，一种姜黄素的合成类似物，是 JAK2/STAT3 的双重抑制剂，具有抗肿瘤癌活性。FLLL32 作用于乳腺癌细胞，可抑制 IFNα 和 IL-6 诱导的 STAT3 磷酸化。;InformationFLLL32 is a potentJAK2/STAT3inhibitor withIC50of <5 μM. FLLL32 inhibits the induction of STAT3 phosphorylation byIFNαandIL-6in breast cancer cells.TargetsJAK2 <5 μMIn vitroIn MDA-MB-231 breast and PANC-1 pancreatic cancer cells, FLLL32 downregulates STAT3 phosphorylation and DNA-binding activity. In MDA-MB-231 cells, FLLL32 inhibit the formation of colonies and cell invasion. In human multiple myeloma, glioblastoma, liver cancer, and colorectal cancer cell lines, FLLL32 also leads to the inhibition of cell proliferation and the induction of caspase-3 and PARP cleavages.In vivoIn MDA-MB-231 xenografted mice, FLLL32 (50 mg/kg, i.p.) significantly reduces tumor burdens. In mouse xenografts with OS-33 osteosarcoma cells, FLLL32 (50 mg/kg, i.p.) also inhibits tumor growth by targeting STAT3.Cell Research(from reference)Cell lines：MDA-MB-231 cell line Concentrations：~5 μM Incubation Time：72 hours |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京