| 体内研究: |
MG 149 (1.6 mg/kg,腹腔注射,每天一次,持续 14 天) 可以逆转雄性 C57BL/6J 小鼠慢性束缚应激 (CRS) 诱导的高血压。 |
| 参考文献: |
1. Ghizzoni M, et al. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem. 2012 Jan;47(1):337-44. 2. de Talhouët C, et al. KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy. Sci Rep. 2024 May 22;14(1):11721. 3. Wang Y, et al. TIP60 mediates stress-induced hypertension via promoting glutamatedmPFC-to-vCA1 release. Clin Exp Hypertens. 2023 Dec 31;45(1):2259130. |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
2.937 ml |
14.686 ml |
29.372 ml |
| 5 mM |
0.587 ml |
2.937 ml |
5.874 ml |
| 10 mM |
0.294 ml |
1.469 ml |
2.937 ml |
| 50 mM |
0.059 ml |
0.294 ml |
0.587 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |