货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T95491-1ml促销	10mM in DMSO	￥1270.00 ￥1140.00 T95491-1ml ￥1140.00 3-5天	0 货期：3-5天	-	-	-	-

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体内研究：

Olumacostat glasaretil is a pro-drug of the ACC inhibitor 5-(tetradecyloxy)-2-furoic acid (TOFA) and is designed to enhance delivery in vivo. Topical application of olumacostat glasaretil but not TOFA significantly reduces hamster ear sebaceous gland size. HPLC analyses of hamster ear extracts shows that olumacostat glasaretil treatment increases ACC levels and the ratio of acetyl-CoA to free CoA in tested animals, indicating increased fatty acid oxidation. These changes are consistent with ACC inhibition. Matrix-assisted laser desorption/ionization (MALDI) imaging reveals that OG applied onto Yorkshire pig ears accumulates in sebaceous glands relative to the surrounding dermis. At week 12, OG treatment shows greater reductions from baseline in inflammatory lesions and noninflammatory lesions, and more patients with greater than or equal to 2-grade improvement in investigator global assessment score than vehicle.

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.076 ml	10.382 ml	20.763 ml
5 mM	0.415 ml	2.076 ml	4.153 ml
10 mM	0.208 ml	1.038 ml	2.076 ml
50 mM	0.042 ml	0.208 ml	0.415 ml

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部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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