货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T95681-1ml促销	10mM in DMSO	￥2750.00 ￥2470.00 T95681-1ml ￥2470.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T95681-1ml促销

10mM in DMSO

￥2750.00 ￥2470.00

货期：3-5天

靶点：

Sigma receptor; 5-HT2 receptor; D2 receptor

体内研究：

DuP 734 potently blocks mescaline-induced scratching (ED50=0.35 mg/kg, p.o.) and aggressive activity (ED50=1.9 mg/kg, p.o.) and is relatively much weaker as an apomorphine antagonist (ED50=12 mg/kg, p.o.).
Administration of DuP 734 potently antagonizes the binding of [3H]DuP 734 and [3H](+)-SKF 10,047 to brain sigma receptors in vivo with ID50 values of 0.02 and 0.07 mg/kg (0.07 and 0.25μmol/kg), respectively.
Following intravenous dosing, the disposition of DuP 734 in mice, rats, beagle dogs and cynomolgus monkeys is characterized by high total body systemic plasma clearance (46 to 87 mL/min/kg) and large steady-state volume of distribution (3.6 to 6.8 L/kg). The terminal elimination half-life ranged from 50 to 83 min. The gastrointestinal absorption from an aqueous solution is very rapid in mice and rats with peak DuP 734 plasma concentrations attain within 5 and 20 min following administration, respectively. The peak plasma concentrations in dogs and monkeys are attained within 45 and 130 min, respectively. The absolute bioavailability in mice ranges from 29 to 46% at doses of 3.1 to 30.1 mg/kg. The bioavailability increases from 4 to 10% and from 14 to 72% when doses are increased from 12.5 to 50 mg/kg and 1 to 3 mg/kg of DuP 734 in rats and dogs, respectively. The bioavailability in monkeys is 30.5% at 9.3 mg/kg DuP 734 dose. The dose dependent pharmacokinetics of DuP 734 is observed within narrow dose ranges in all animal species investigated.

保存条件：

-80℃，充氩（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.807 ml	14.034 ml	28.069 ml
5 mM	0.561 ml	2.807 ml	5.614 ml
10 mM	0.281 ml	1.403 ml	2.807 ml
50 mM	0.056 ml	0.281 ml	0.561 ml

注意：

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参考文献

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