货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T95789-1ml促销	10mM in DMSO	￥1200.00 ￥1080.00 T95789-1ml ￥1080.00 现货	5 5	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T95789-1ml促销

10mM in DMSO

￥1200.00 ￥1080.00

产品描述：

p110δ 选择性抑制剂;p110δ Selective Inhibitors;;InformationPIK-III (VPS34-IN2), which is a selective inhibitor of VPS34 enzymatic activity, inhibitsautophagyand de novo lipidation of LC3 and leads to the stabilization of autophagy substrates. The IC50 values for VPS34 and PI(3)Kδ are 0.018 μM and 1.2 μM respectively.TargetsVps34 (Cell-free assay); PI3Kδ (Cell-free assay) 0.018μM; 1.2μMIn vitroVPS34 enzymatic function is essential for LC3 lipidation in mammalian cells and PIK-III is a robust inhibitor of autophagy and LC3 lipidation in mammalian cells.In H4 cells, PIK-III inhibits the formation of autolysosomes and increases the cytosolic signal of LC3 under basal conditions and when autophagy is induced with the mTOR inhibitor AZD8055.In a CCCP-induced mitophagy model, PIK-III inhibits the clearance of mitochondria.PIK-III treatment leads to an increase in the levels of LC3-I in H4 and PSN1 cells.In Panc10.05 cells, PIK-III increases the levels of LC3-II in parallel with LC3-I suggesting a cell type-specific response.Cell Research(from reference)Cell lines：H4 cells/ HeLa cells Concentrations：2.5μM in H4 cells/5μM in Hela cells Incubation Time：overnight for H4 cells/12h for Hela cells

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.131 ml	15.656 ml	31.313 ml
5 mM	0.626 ml	3.131 ml	6.263 ml
10 mM	0.313 ml	1.566 ml	3.131 ml
50 mM	0.063 ml	0.313 ml	0.626 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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