货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T95876-1ml促销	10mM in DMSO	￥720.00 ￥648.00 T95876-1ml ￥648.00 现货	3 3	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T95876-1ml促销

10mM in DMSO

￥720.00 ￥648.00

产品描述：

ROS抑制剂;ROS Inhibitors;;InformationGSK2795039 GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis .TargetsROS ; NADPH ; NOX2 (HRP/Amplex Red) (Cell-based assay) ; 6.57(pIC50)In vitroGSK2795039 inhibits both the formation of ROS and the utilization of the enzyme substrates, NADPH and oxygen, in a variety of semirecombinant cell-free and cell-based NOX2 assays. GSK2795039 inhibits NOX2 in an NADPH competitive manner and is selective over other NOX isoforms, xanthine oxidase, and endothelial nitric oxide synthase enzymes.In vivoFollowing systemic administration in mice, GSK2795039 abolishes the production of ROS by activated NOX2 enzyme in a paw inflammation model. GSK2795039 shows activity in a murine model of acute pancreatitis, reducing the levels of serum amylase triggered by systemic injection of cerulein.Cell Research(from reference)Cell lines：NOX isoform-specific cells, PBMCs, PMNs, HL60 cells Concentrations：3.16 nM, 10 nM, 31.6 nM, 100 nM, 316 nM, 1μM, 3.16 μM, 10 μM, 31.6 μM, 100μM Incubation Time：10 min, 20 min, 30 min, 40 min, 50 min, 60 min

体内研究：

GSK2795039（腹膜内注射；100 mg/kg；1 小时前）可降低小鼠急性胰腺炎模型的活动性，从而降低全身注射 cerulein 引起的血清淀粉酶水平。

参考文献：

1. Hirano K, et al. Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor. Antioxid Redox Signal. 2015 Aug 10;23(5):358-74.
2. Yauger YJ, et al. Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro. J Neuroinflammation. 2019 Feb 18;16(1):41.

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.219 ml	11.097 ml	22.195 ml
5 mM	0.444 ml	2.219 ml	4.439 ml
10 mM	0.222 ml	1.11 ml	2.219 ml
50 mM	0.044 ml	0.222 ml	0.444 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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