货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T95934-1ml促销	10mM in DMSO	￥712.00 ￥640.00 T95934-1ml ￥640.00 现货	5 5	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T95934-1ml促销

10mM in DMSO

￥712.00 ￥640.00

产品描述：

mTOR抑制剂;mTOR Inhibitors;;InformationCZ415 CZ415, a potent ATP-competitive mTOR inhibitor with very good cell permeability.TargetsmTOR (Cell-free assay) 8.07(pIC50)In vitroCZ415 shows no genotoxic potential and has very good cell permeability. Treatment of CZ415 leads to inhibition of phosphorylation for downstream targets of mTORC1 and mTORC2(IC50=14.5 nM for pS6RP and IC50=14.8 nM for pAKT). The immunosuppressive effect of CZ415 is measured by detecting secreted IFNγ after 18 h in stimulated human whole blood, and the resulting IC50 was 226 nM. CZ415 shows no genotoxic potential. It is neither mutagenic in a bacterial mutation assay (Ames test) nor does it show genotoxicity in the mouse lymphoma assay (MLA), in either the presence or absence of rat-liver S9 mix.In vivoIn vivo studies show that CZ415 has moderate clearance and good oral bioavailability. In an anti-CD3 mouse model CZ415 efficiently inhibits mTOR downstream signaling and, in a CIA mouse model, shows significant antiinflammatory effects. With its extraordinary selectivity, drug-like properties and proven efficacy CZ415 represents an ideal molecule for the pharmacological investigation of mTOR pathophysiological role in vivo.Cell Research(from reference)Cell lines：HEK294T17 cells Concentrations：3 µM start, 8 points 1:3 dilution steps. Incubation Time：2 h

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.176 ml	10.88 ml	21.76 ml
5 mM	0.435 ml	2.176 ml	4.352 ml
10 mM	0.218 ml	1.088 ml	2.176 ml
50 mM	0.044 ml	0.218 ml	0.435 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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