| 产品描述： | HDAC8 选择性抑制剂;HDAC8 Selective Inhibitors;;InformationHPOB is a potent, selectiveHDAC6inhibitor withIC50of 56 nM, >30-fold selectivity over other HDACs.TargetsHDAC6 ; HDAC3 ; HDAC8 ; HDAC1 ; HDAC10 14965,56 nM; 1.7 μM; 2.8 μM; 2.9 μM; 3.0 μMIn vitroIn normal (HFS) and transformed (LNCaP, A549, and U87) cells, HPOB induces acetylation of α-tubulin, however, not histones, and inhibits cell growth, however, not viability. In HFS cells, HPOB enhances transformed cell death induced by etoposide, doxorubicin, or SAHA. HPOB also enhancing etoposide-induced transformed cell death via the apoptotic pathway in transformed cells.In vivoIn mice bearing CWR22 human prostate cancer xenografts, HPOB (300 mg/kg/d i.p.), when in combination with SAHA, causes suppression of the growth of established tumors, while produces no significant suppression when used alone.Cell Research(from reference)Cell lines：HFS, A549, LNCaP, and U87 cells Concentrations：~32 μM Incubation Time：72 hours |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京