货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T96029-1ml促销	10mM in DMSO	￥720.00 ￥648.00 T96029-1ml ￥648.00 现货	4 4	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T96029-1ml促销

10mM in DMSO

￥720.00 ￥648.00

产品描述：

FLT3 抑制剂;FLT3 Inhibitors;;InformationG-749 G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y), and Mer, respectively, showing lower potency against other tyrosine kinases.TargetsFLT3 (Cell-free assay); FLT3 (D835Y) (Cell-free assay); Mer (Cell-free assay); Aurora B (Cell-free assay); RET (Cell-free assay) 15501,0.4 nM; 0.6 nM; 1 nM; 6 nM; 9 nMIn vitroIn FLT3-WT-bearing RS4-11 cells and FLT3-ITD-harboring MV4-11 and Molm-14 cells, G-749 potently inhibits autophosphorylation of FLT3 with IC50 of ≤8 nM. In leukemia cells, G-749 shows antiproliferative activity by inducing apoptosis. In BaF3 cell lines that stably express FLT3-ITD/N676D, FLT3-ITD/F691L, FLT3-D835Y, or FLT3-D835Y/N676D, G-749 shows strong inhibitory activity with IC50 of <10 nM, and thus overcomes drug resistance. In blasts of AML patients, G-749 also exhibits potent antileukemia activity.In vivoIn MV4-11 xenograft mice, G-749 (30 mg/kg p.o.) effectively inhibits the FLT3 pathway and significant inhibits tumor growth. In an orthogonal model of bone marrow engraftment using Molm-14 cells, G-749 (20 mg/kg p.o.) also inhibits tumor growth and increases survival.Cell Research(from reference)Cell lines：MV4-11, RS4-11, K562, HEL, and Molm-14 cells Concentrations：~1 μM Incubation Time：72 hours

靶点：

IC50: 0.4 nM (FLT3-WT), 0.6 nM (FLT3-D835Y)

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.918 ml	9.589 ml	19.179 ml
5 mM	0.384 ml	1.918 ml	3.836 ml
10 mM	0.192 ml	0.959 ml	1.918 ml
50 mM	0.038 ml	0.192 ml	0.384 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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