| 产品描述: | 产品介绍:GJ-103 是一种 GJ072 的活性类似物,它是一种通读化合物 (RTC)。化学诱导的提前终止密码子的通读可能被用作针对由无意义突变引起的遗传疾病的潜在治疗策略。;InformationGJ-103 is an active analog of GJ072 which is a read-through compound (RTC). Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations. |
| 体内研究: |
GJ103 (10-30 μM; 4 days) 在具有纯合 TGA 突变和纯合 TAA 突变的 AT153LA 细胞中诱导 ATM 激酶活性。 GJ103 在浓度高达 300 µM 时对 A-T 细胞没有表现出明显的细胞毒性。 |
| 参考文献: |
1. Du L, et, al. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60. |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
2.921 ml |
14.604 ml |
29.208 ml |
| 5 mM |
0.584 ml |
2.921 ml |
5.842 ml |
| 10 mM |
0.292 ml |
1.46 ml |
2.921 ml |
| 50 mM |
0.058 ml |
0.292 ml |
0.584 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |