| 产品描述: | 微管相关抑制剂;Microtubule Associated Inhibitors;;InformationCW069 CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP.TargetsHSET 75 μMIn vitroCW069 increases multipolar spindles in N1E-115 cells with supernumerary centrosomes without altering bipolar spindle morphology in normal human dermal fibroblast cells. CW069 inhibits growth in cancer N1E-115 cells with IC50 of 10 μM, but not in NHDF or primary human bone marrow cells.Cell Research(from reference)Cell lines:N1E-115 cells, NHDF and primary human bone marrow cells. Concentrations:~400 μM Incubation Time:72 hours |