货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T96209-1ml	10mM in DMSO	￥570.00 T96209-1ml ￥570.00 现货	1 1	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T96209-1ml

10mM in DMSO

￥570.00

产品描述：

CDK9 选择性抑制剂;CDK9 Selective Inhibitors;;InformationBAY1251152 is a potentPTEFb/CDK9inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins.TargetsCDK9 (Cell-free assay) 3 nMIn vitroBAY 1251152 (compound 2) significantly inhibits CDK9 and CDK2 with IC50 of 3 nM and 360 nM, respectively. BAY 1251152 (compound 2) shows cellular potency in MOLM13 with IC50 of 29 nM.In vivoBAY 1251152 demonstrates excellent efficacy upon i.v. treatment in xenograft models (e.g. MOLM13) in mice and rats. BAY 1251152 is currently being evaluated in Phase I studies to determine the safety, tolerability, pharmacokinetics and initial pharmacodynamic biomarker response in patients with advanced cancer.Cell Research(from reference)Cell lines：HeLa, NCI-H460, A2780, DU 145, HeLa-MaTu-ADR, Caco-2, B16F10, MOLM-13 Concentrations：0.001 μM - 10 μM Incubation Time：4 days

保存条件：

避光,-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.473 ml	12.363 ml	24.726 ml
5 mM	0.495 ml	2.473 ml	4.945 ml
10 mM	0.247 ml	1.236 ml	2.473 ml
50 mM	0.049 ml	0.247 ml	0.495 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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